Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase-activating protein' and Ligand = 'BDBM145821'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145821 (US8952177, 177 | US9089569, 177 | US9695149, 177) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r| Show InChI InChI=1S/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145821 (US8952177, 177 | US9089569, 177 | US9695149, 177) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r| Show InChI InChI=1S/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145821 (US8952177, 177 | US9089569, 177 | US9695149, 177) Show SMILES CC1CCN(CC1)c1ccc(Cn2c(nc3ccc(OCc4ncc(C)cc4F)cc23)[C@@H]2CCCC[C@@H]2C(O)=O)c(F)c1 |r| Show InChI InChI=1S/C34H38F2N4O3/c1-21-11-13-39(14-12-21)24-8-7-23(28(35)16-24)19-40-32-17-25(43-20-31-29(36)15-22(2)18-37-31)9-10-30(32)38-33(40)26-5-3-4-6-27(26)34(41)42/h7-10,15-18,21,26-27H,3-6,11-14,19-20H2,1-2H3,(H,41,42)/t26-,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair