BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Arginase-1' and Ligand = 'BDBM50008099'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	517	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Rattus norvegicus)	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of rat Arg1 at pH 7.4				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Rattus norvegicus)	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
New England Discovery Partners Curated by ChEMBL					Assay Description Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...				J Med Chem 62: 8164-8177 (2019) Article DOI: 10.1021/acs.jmedchem.9b00931 BindingDB Entry DOI: 10.7270/Q2X92FM9
New England Discovery Partners Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Rattus norvegicus)	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of rat liver arginase				Eur J Med Chem 76: 132-44 (2014) Article DOI: 10.1016/j.ejmech.2014.02.008 BindingDB Entry DOI: 10.7270/Q2T43VM0
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Bos taurus)	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis				Citation and Details Article DOI: 10.1039/d0md00011f BindingDB Entry DOI: 10.7270/Q261140V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	517	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human Arg1 at pH 8.5				Citation and Details Article DOI: 10.1016/j.bmc.2020.115658 BindingDB Entry DOI: 10.7270/Q2WS8XZC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Arginase-1 (Homo sapiens (Human))	BDBM50008099 (CHEMBL1234777) Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to arginase 1 (unknown origin)				Citation and Details Article DOI: 10.1016/j.bmcl.2017.12.044 BindingDB Entry DOI: 10.7270/Q2736THR
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)