Found 2 hits Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor 1' and Ligand = 'BDBM50452463' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452463
(CHEMBL4206328)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.11,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.4,-11.69,;20.41,-10.15,;21.75,-9.4,;23.07,-10.18,;23.06,-11.71,;24.38,-12.49,;21.73,-12.46,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H40FN7O2/c1-19(18-39)32-29-36-27-13-8-21(20-5-3-6-22(31)15-20)16-26(27)28(37-29)33-23-9-11-24(12-10-23)34-30(40)35-25-7-4-14-38(2)17-25/h3,5-6,8,13,15-16,19,23-25,39H,4,7,9-12,14,17-18H2,1-2H3,(H2,34,35,40)(H2,32,33,36,37)/t19-,23-,24+,25?/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452463
(CHEMBL4206328)Show SMILES C[C@H](CO)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CCCN(C)C2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:9.8,12.15,1.0,(15.1,-7.01,;15.11,-5.48,;16.43,-4.73,;17.75,-5.51,;13.79,-4.72,;12.45,-5.48,;12.45,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.1,-10.11,;13.77,-9.34,;16.42,-12.43,;17.75,-11.67,;17.76,-10.15,;19.07,-12.45,;20.4,-11.69,;20.41,-10.15,;21.75,-9.4,;23.07,-10.18,;23.06,-11.71,;24.38,-12.49,;21.73,-12.46,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.12,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.11,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C30H40FN7O2/c1-19(18-39)32-29-36-27-13-8-21(20-5-3-6-22(31)15-20)16-26(27)28(37-29)33-23-9-11-24(12-10-23)34-30(40)35-25-7-4-14-38(2)17-25/h3,5-6,8,13,15-16,19,23-25,39H,4,7,9-12,14,17-18H2,1-2H3,(H2,34,35,40)(H2,32,33,36,37)/t19-,23-,24+,25?/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006
BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this
Ligand-Target Pair | |
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