Found 2 hits Enz. Inhib. hit(s) with Target = 'Atrial natriuretic peptide receptor 1' and Ligand = 'BDBM50452468' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Atrial natriuretic peptide receptor 1
(Rattus norvegicus) | BDBM50452468
(CHEMBL4205090)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at rat NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 15 mins by fluorescent assay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |
Atrial natriuretic peptide receptor 1
(Homo sapiens (Human)) | BDBM50452468
(CHEMBL4205090)Show SMILES CC(C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)N[C@@H](CO)C(C)C)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:8.7,11.14,wD:18.21,(15.1,-7.02,;15.1,-5.48,;16.43,-4.72,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.41,-11.68,;21.73,-12.46,;23.06,-11.7,;20.42,-10.15,;21.75,-9.39,;19.1,-9.37,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)| Show InChI InChI=1S/C29H39FN6O2/c1-17(2)26(16-37)35-29(38)33-23-11-9-22(10-12-23)32-27-24-15-20(19-6-5-7-21(30)14-19)8-13-25(24)34-28(36-27)31-18(3)4/h5-8,13-15,17-18,22-23,26,37H,9-12,16H2,1-4H3,(H2,33,35,38)(H2,31,32,34,36)/t22-,23+,26-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay |
Bioorg Med Chem 25: 6680-6694 (2017)
Article DOI: 10.1016/j.bmc.2017.11.006 BindingDB Entry DOI: 10.7270/Q2ZW1PG6 |
More data for this Ligand-Target Pair | |