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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM50535101'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))		BDBM50535101
PNG
(CHEMBL4444533)
Show SMILES CN(C)c1ccc(cn1)-c1cc2nccnc2c(NCC(F)(F)F)n1
Show InChI InChI=1S/C16H15F3N6/c1-25(2)13-4-3-10(8-22-13)11-7-12-14(21-6-5-20-12)15(24-11)23-9-16(17,18)19/h3-8H,9H2,1-2H3,(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal-6His-tagged full length human Aurora B expressed in baculovirus using 5FAM-PKA-tide as substrate after 120 mins by fluoresce...

Bioorg Med Chem Lett 26: 4606-4612 (2016)


Article DOI: 10.1016/j.bmcl.2016.08.070
BindingDB Entry DOI: 10.7270/Q2GM8BT3
More data for this
Ligand-Target Pair