Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor (Rattus norvegicus (Rat)) | BDBM25762 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 2.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy Curated by PDSP Ki Database | Jpn J Pharmacol 52: 195-200 (1990) Article DOI: 10.1254/jjp.52.195 BindingDB Entry DOI: 10.7270/Q2H41PXD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM25762 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories Curated by ChEMBL | Assay Description Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogs | J Med Chem 33: 2883-91 (1990) BindingDB Entry DOI: 10.7270/Q2416XN5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM25762 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories Curated by ChEMBL | Assay Description In vitro Beta-1 adrenergic receptor affinity in partially purified membrane fractions from canine cardiac tissue using [SH]dihydroalprenolol (4.5 nM) | J Med Chem 33: 1087-90 (1990) BindingDB Entry DOI: 10.7270/Q2DB82FG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM25762 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories Curated by ChEMBL | Assay Description Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular... | J Med Chem 35: 743-50 (1992) BindingDB Entry DOI: 10.7270/Q2319TT0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM25762 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG PC cid PC sid UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | 7.4 | 37 |
University of Nottingham | Assay Description The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined... | Br J Pharmacol 144: 317-22 (2005) Article DOI: 10.1038/sj.bjp.0706048 BindingDB Entry DOI: 10.7270/Q28C9TKV | |||||||||||
More data for this Ligand-Target Pair |