Found 9 hits Enz. Inhib. hit(s) with Target = 'Beta-2 adrenergic receptor' and Ligand = 'BDBM25762' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-2 adrenergic receptor
(Rattus norvegicus) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| 339 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195 BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 568-80 (1976)
BindingDB Entry DOI: 10.7270/Q2ZK5F5P |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 568-80 (1976)
BindingDB Entry DOI: 10.7270/Q2ZK5F5P |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Canis familiaris) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti... |
J Med Chem 35: 743-50 (1992)
BindingDB Entry DOI: 10.7270/Q2319TT0 |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Canis familiaris) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description In vitro Beta-2 adrenergic receptor affinity in partially purified membrane fractions from canine lung tissue using [SH]dihydroalprenolol (4.5 nM) |
J Med Chem 33: 1087-90 (1990)
BindingDB Entry DOI: 10.7270/Q2DB82FG |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Canis familiaris) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Laboratories
Curated by ChEMBL
| Assay Description Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogs |
J Med Chem 33: 2883-91 (1990)
BindingDB Entry DOI: 10.7270/Q2416XN5 |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(BOVINE) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
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| PubMed
| n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) |
J Med Chem 28: 1328-34 (1985)
BindingDB Entry DOI: 10.7270/Q2HX1DZG |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(BOVINE) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
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| PubMed
| n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) |
J Med Chem 28: 1328-34 (1985)
BindingDB Entry DOI: 10.7270/Q2HX1DZG |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM25762
(CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
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| DrugBank Article PubMed
| n/a | n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
| Assay Description The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined... |
Br J Pharmacol 144: 317-22 (2005)
Article DOI: 10.1038/sj.bjp.0706048 BindingDB Entry DOI: 10.7270/Q28C9TKV |
More data for this Ligand-Target Pair | |