BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Beta-3 adrenergic receptor' and Ligand = 'BDBM50075889'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonistic activity against the cloned human Beta-3 adrenergic receptor was measured by its by its ability to stimulate adenylyl cyclase				Bioorg Med Chem Lett 9: 1251-4 (1999) BindingDB Entry DOI: 10.7270/Q2RB73RN
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity towards Beta-3 adrenergic receptor				Bioorg Med Chem Lett 9: 749-54 (1999) BindingDB Entry DOI: 10.7270/Q22Z14QB
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity of the compound towards Beta-3 adrenergic receptor				Bioorg Med Chem Lett 9: 755-8 (1999) BindingDB Entry DOI: 10.7270/Q2Z60N7C
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	7.08E+7	n/a	n/a	n/a	n/a
Central Drug Research Institute Curated by ChEMBL					Assay Description In vitro effective concentration against beta-3 adrenergic receptor.				Bioorg Med Chem Lett 13: 2481-4 (2003) BindingDB Entry DOI: 10.7270/Q2GT5MK6
Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Tested in vitro for its ability to stimulate increase in cAMP in CHO cellsexpressing the cloned human beta-3 adrenergic receptor				Bioorg Med Chem Lett 10: 2111-4 (2000) BindingDB Entry DOI: 10.7270/Q2X929JR
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Central Drug Research Institute Curated by ChEMBL					Assay Description In vitro effective concentration against beta-3 adrenergic receptor.				Bioorg Med Chem Lett 13: 2481-4 (2003) BindingDB Entry DOI: 10.7270/Q2GT5MK6
Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-3 adrenergic receptor (Homo sapiens (Human))	BDBM50075889 (4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro agonistic activity against cloned human beta-3 adrenergic receptor using [125I]-iodocyanopindolol as radioligand to stimulate increase in cA...				Bioorg Med Chem Lett 9: 1869-74 (1999) BindingDB Entry DOI: 10.7270/Q2FN15D1
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair