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Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM402433'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))		BDBM402433
PNG
(US10329291, Example 32)
Show SMILES CN1C(=N)NC2(CC2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1S/C17H15ClFN5O3S/c1-24-16(20)23-17(7-14(17)28(24,26)27)11-6-10(3-4-12(11)19)22-15(25)13-5-2-9(18)8-21-13/h2-6,8,14H,7H2,1H3,(H2,20,23)(H,22,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 2.52E+3n/an/an/an/an/an/an/an/a



Vernalis (R&D) Ltd



Assay Description
The compounds of the invention were assessed for their ability to inhibit BACE-1 using the following assay. The resulting values are reported in the ...

Bioorg Med Chem 17: 6590-605 (2009)


BindingDB Entry DOI: 10.7270/Q2ZW1P72
More data for this
Ligand-Target Pair