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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM50074731'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional dihydrofolate reductase-thymidylate synthase


(Toxoplasma gondii)		BDBM50074731
PNG
(6-(3-(trifluoromethyl)benzyl)-5,6,7,8-tetrahydroqu...)
Show SMILES Nc1nc(N)c2CC(Cc3cccc(c3)C(F)(F)F)CCc2n1
Show InChI InChI=1S/C16H17F3N4/c17-16(18,19)11-3-1-2-9(7-11)6-10-4-5-13-12(8-10)14(20)23-15(21)22-13/h1-3,7,10H,4-6,8H2,(H4,20,21,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
The ability of the compound to inhibit T. gondii Dihydrofolate reductase was tested

J Med Chem 42: 1007-17 (1999)


Article DOI: 10.1021/jm980572i
BindingDB Entry DOI: 10.7270/Q2513XCR
More data for this
Ligand-Target Pair