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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM50531788'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional dihydrofolate reductase-thymidylate synthase


(Toxoplasma gondii)		BDBM50531788
PNG
(CHEMBL4519642)
Show SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2ccccn2)c(N)n1
Show InChI InChI=1S/C19H21N7/c20-18-17(13-23-19(21)24-18)26-10-8-25(9-11-26)15-5-3-4-14(12-15)16-6-1-2-7-22-16/h1-7,12-13H,8-11H2,(H4,20,21,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Vyera Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...

J Med Chem 62: 1562-1576 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01754
BindingDB Entry DOI: 10.7270/Q2T43XJX
More data for this
Ligand-Target Pair