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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial' and Ligand = 'BDBM50535663'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial


(Homo sapiens (Human))		BDBM50535663
PNG
(CHEMBL4467548)
Show SMILES OC(=O)c1ccc(cn1)C(=O)N1CCc2nc([nH]c(=O)c2C1)-c1ccccc1
Show InChI InChI=1S/C20H16N4O4/c25-18-14-11-24(19(26)13-6-7-16(20(27)28)21-10-13)9-8-15(14)22-17(23-18)12-4-2-1-3-5-12/h1-7,10H,8-9,11H2,(H,27,28)(H,22,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...

ACS Med Chem Lett 10: 893-898 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00069
BindingDB Entry DOI: 10.7270/Q2J67MFK
More data for this
Ligand-Target Pair