Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM24689 (10-methoxy-DDACTHF, 10R-8 | 2-({4-[(1R)-4-(2,4-dia...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | >-22.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 26 |
The Scripps Research Institute | Assay Description Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo... | J Med Chem 51: 5441-8 (2008) Article DOI: 10.1021/jm800555h BindingDB Entry DOI: 10.7270/Q2WD3XVB | |||||||||||
More data for this Ligand-Target Pair |