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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4' and Ligand = 'BDBM320308'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))		BDBM320308
PNG
(US10174024, Example 25 | tert-Butyl 4-[3-(dimethyl...)
Show SMILES Cc1nnn(C)c1-c1cnc2c(c1)n([C@@H](C1CCOCC1)c1ccccc1)c1c(ccc(N3CCN(CC3)C(=O)OC(C)(C)C)c21)S(C)(=O)=O |r|
Show InChI InChI=1S/C37H45N7O5S/c1-24-33(41(5)40-39-24)27-22-29-32(38-23-27)31-28(42-16-18-43(19-17-42)36(45)49-37(2,3)4)12-13-30(50(6,46)47)35(31)44(29)34(25-10-8-7-9-11-25)26-14-20-48-21-15-26/h7-13,22-23,26,34H,14-21H2,1-6H3/t34-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...

US Patent US10174024 (2019)


BindingDB Entry DOI: 10.7270/Q2319XZ1
More data for this
Ligand-Target Pair