Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL | Assay Description Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method | Eur J Med Chem 115: 14-25 (2016) Article DOI: 10.1016/j.ejmech.2016.02.058 BindingDB Entry DOI: 10.7270/Q24J0J4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre Curated by ChEMBL | Assay Description Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay | Eur J Med Chem 115: 14-25 (2016) Article DOI: 10.1016/j.ejmech.2016.02.058 BindingDB Entry DOI: 10.7270/Q24J0J4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPR | Bioorg Med Chem Lett 16: 204-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.022 BindingDB Entry DOI: 10.7270/Q2GH9HHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]MDC from human CCR4 expressed in HEK293 cells | Bioorg Med Chem Lett 17: 679-82 (2007) Article DOI: 10.1016/j.bmcl.2006.10.091 BindingDB Entry DOI: 10.7270/Q24B310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells | Bioorg Med Chem Lett 16: 204-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.022 BindingDB Entry DOI: 10.7270/Q2GH9HHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (Homo sapiens (Human)) | BDBM50175665 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of chemotaxis of murine CCR4 transfected L1.2 cells | Bioorg Med Chem Lett 16: 204-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.022 BindingDB Entry DOI: 10.7270/Q2GH9HHG | |||||||||||
More data for this Ligand-Target Pair |