Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Chymase' and Ligand = 'BDBM134266'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Homo sapiens (Human))	BDBM134266 (US8846660, 40) Show SMILES COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1ccc(F)cc1 |r| Show InChI InChI=1S/C30H30ClFN4O6/c1-18(20-5-3-19(4-6-20)13-28(37)38)34-30(40)36-17-27(35-42-25-10-8-24(32)9-11-25)33-16-22(29(36)39)14-21-15-23(31)7-12-26(21)41-2/h3-12,15,18,22H,13-14,16-17H2,1-2H3,(H,33,35)(H,34,40)(H,37,38)/t18-,22?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Daiichi Sankyo Company, Ltd. US Patent					Assay Description The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...				US Patent US8846660 (2014) BindingDB Entry DOI: 10.7270/Q22V2DTB
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