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Found 1 hit Enz. Inhib. hit(s) with Target = 'Coagulation factor XI' and Ligand = 'BDBM303786'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor XI


(Homo sapiens (Human))		BDBM303786
PNG
(4-{[(11-Chloro-2,5-dioxo-5,6,7,8-tetrahydropyrido[...)
Show SMILES OC(=O)c1ccc(NC(=O)Cn2cc3c(cc2=O)-c2cc(Cl)ccc2CCNC3=O)cc1 |$;;;;;;;HN;;;;;;;;;;;;;;;;;;;;HN;;;;$|
Show InChI InChI=1S/C23H18ClN3O5/c24-15-4-1-13-7-8-25-22(30)19-11-27(21(29)10-18(19)17(13)9-15)12-20(28)26-16-5-2-14(3-6-16)23(31)32/h1-6,9-11H,7-8,12H2,(H,25,30)(H,26,28)(H,31,32)
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US Patent
n/an/a 720n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...

US Patent US10138236 (2018)


BindingDB Entry DOI: 10.7270/Q2445PH4
More data for this
Ligand-Target Pair