Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM50540311'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM50540311 (CHEMBL4646504) Show SMILES CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H28N2O3/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(29-3)13-22(26)17-4-6-18(7-5-17)24(27)28/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3,(H,27,28)/t19-,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human serine protease factor B by TR-FRET based competition binding assay				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM50540311 (CHEMBL4646504) Show SMILES CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H28N2O3/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(29-3)13-22(26)17-4-6-18(7-5-17)24(27)28/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3,(H,27,28)/t19-,22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair
Complement factor B (Mus musculus)	BDBM50540311 (CHEMBL4646504) Show SMILES CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C24H28N2O3/c1-15-12-16(2)23-20(8-10-25-23)21(15)14-26-11-9-19(29-3)13-22(26)17-4-6-18(7-5-17)24(27)28/h4-8,10,12,19,22,25H,9,11,13-14H2,1-3H3,(H,27,28)/t19-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair