Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM50540312'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM50540312 (CHEMBL4641109) Show SMILES CO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H30N2O3/c1-16-13-22(17-3-4-17)23(21-9-11-27-25(16)21)15-28-12-10-20(31-2)14-24(28)18-5-7-19(8-6-18)26(29)30/h5-9,11,13,17,20,24,27H,3-4,10,12,14-15H2,1-2H3,(H,29,30)/t20-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human serine protease factor B by TR-FRET based competition binding assay				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair
Complement factor B (Mus musculus)	BDBM50540312 (CHEMBL4641109) Show SMILES CO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H30N2O3/c1-16-13-22(17-3-4-17)23(21-9-11-27-25(16)21)15-28-12-10-20(31-2)14-24(28)18-5-7-19(8-6-18)26(29)30/h5-9,11,13,17,20,24,27H,3-4,10,12,14-15H2,1-2H3,(H,29,30)/t20-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM50540312 (CHEMBL4641109) Show SMILES CO[C@H]1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H30N2O3/c1-16-13-22(17-3-4-17)23(21-9-11-27-25(16)21)15-28-12-10-20(31-2)14-24(28)18-5-7-19(8-6-18)26(29)30/h5-9,11,13,17,20,24,27H,3-4,10,12,14-15H2,1-2H3,(H,29,30)/t20-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...				J Med Chem 63: 5697-5722 (2020) Article DOI: 10.1021/acs.jmedchem.9b01870 BindingDB Entry DOI: 10.7270/Q21N84P4
					More data for this Ligand-Target Pair