Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM131859'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM131859 (US8835444, 1.4) Show SMILES OC(=O)Cc1ccc(NC[C@H]2CC[C@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)cc1 |r,wU:13.16,10.9,(11.34,3.85,;10,3.08,;10,1.54,;8.67,3.85,;7.34,3.08,;7.34,1.54,;6,.77,;4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-3.33,-1.54,;-4.67,-.77,;-4.67,.77,;-6,-1.54,;-7.34,-.77,;-8.67,-1.54,;-8.67,-3.08,;-7.34,-3.85,;-6,-3.08,;-4.67,-3.85,;-10,-.77,;-11.34,-1.54,;-10,.77,;-11.34,,;4.67,3.08,;6,3.85,)| Show InChI InChI=1S/C23H24ClF3N2O3/c24-20-10-5-16(23(25,26)27)12-19(20)22(32)29-18-8-3-15(4-9-18)13-28-17-6-1-14(2-7-17)11-21(30)31/h1-2,5-7,10,12,15,18,28H,3-4,8-9,11,13H2,(H,29,32)(H,30,31)/t15-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	n/a	n/a	948	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
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