Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM131876'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM131876 (US8835444, 5.1) Show SMILES CCc1cc(CC)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)n1 |r,wU:12.15,wD:9.8,(9.87,1.17,;8.78,2.26,;7.29,1.86,;6.82,.39,;5.28,.39,;4.51,-.94,;5.28,-2.27,;4.8,1.86,;3.47,2.63,;2.13,1.86,;.8,2.63,;-.53,1.86,;-.53,.32,;.8,-.45,;2.13,.32,;-1.87,-.45,;-3.2,.32,;-3.2,1.86,;-4.53,-.45,;-5.87,.32,;-7.2,-.45,;-7.2,-1.99,;-5.87,-2.76,;-4.53,-1.99,;-3.2,-2.76,;-8.54,.32,;-9.87,-.45,;-8.54,1.86,;-9.87,1.09,;6.05,2.76,)| Show InChI InChI=1S/C22H27ClF3N3O/c1-3-16-12-18(4-2)29(28-16)13-14-5-8-17(9-6-14)27-21(30)19-11-15(22(24,25)26)7-10-20(19)23/h7,10-12,14,17H,3-6,8-9,13H2,1-2H3,(H,27,30)/t14-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
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