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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50354971'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354971
PNG
(CHEMBL1836936)
Show SMILES COc1ccc(cc1)-n1c(CC(C)C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12
Show InChI InChI=1S/C24H31N5O/c1-14(2)13-20-27-22-23(28-21(16-5-6-16)17-7-8-17)25-15(3)26-24(22)29(20)18-9-11-19(30-4)12-10-18/h9-12,14,16-17,21H,5-8,13H2,1-4H3,(H,25,26,28)
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PubMed
 607n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation

Bioorg Med Chem Lett 21: 6108-11 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.040
BindingDB Entry DOI: 10.7270/Q2F19046
More data for this
Ligand-Target Pair