Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50354982'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50354982 (CHEMBL1836946) Show SMILES COc1ccc(c(Cl)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(24.71,-51.72,;25.46,-50.37,;24.66,-49.05,;23.12,-49.08,;22.33,-47.76,;23.08,-46.42,;24.61,-46.38,;25.36,-45.03,;25.41,-47.7,;22.29,-45.1,;23.2,-43.84,;24.74,-43.84,;22.29,-42.59,;20.81,-43.07,;19.48,-42.3,;19.47,-40.76,;18.14,-40,;18.13,-38.46,;18.9,-37.13,;17.36,-37.13,;16.81,-40.77,;15.27,-40.77,;16.04,-42.11,;18.15,-43.07,;18.15,-44.62,;16.81,-45.39,;19.48,-45.39,;20.82,-44.62,)| Show InChI InChI=1S/C21H24ClN5O/c1-11-23-20(26-18(13-4-5-13)14-6-7-14)19-21(24-11)27(12(2)25-19)17-9-8-15(28-3)10-16(17)22/h8-10,13-14,18H,4-7H2,1-3H3,(H,23,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation				Bioorg Med Chem Lett 21: 6108-11 (2011) Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046
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