Found 4 hits Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50387015' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.114085
BindingDB Entry DOI: 10.7270/Q2XW4PS2 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50387015
(CHEMBL2049190)Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)c(=O)[nH]c12 Show InChI InChI=1S/C23H30N4O/c1-6-11-27(12-7-2)19-10-8-9-18-21(19)26-23(28)22(24-18)25-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated intracellular cAMP accumulation preincu... |
Bioorg Med Chem Lett 22: 4756-61 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.066
BindingDB Entry DOI: 10.7270/Q21837JW |
More data for this
Ligand-Target Pair | |
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