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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cruzipain' and Ligand = 'BDBM50386180'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cruzipain


(Trypanosoma cruzi)		BDBM50386180
PNG
(CHEMBL2042792)
Show SMILES COc1cc(\C=C\C(=O)N\N=C\c2ccccc2O)cc(c1OC)[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O6/c1-26-16-10-12(9-14(21(24)25)18(16)27-2)7-8-17(23)20-19-11-13-5-3-4-6-15(13)22/h3-11,22H,1-2H3,(H,20,23)/b8-7+,19-11+
PDB
MMDB

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 8.39E+4n/an/an/an/an/an/a



Instituto de Tecnologia em F£rmacos - Farmanguinhos

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi C-terminally truncated cruzain expressed in Escherichia coli using Z-Phe-Arg-AMC as substrate incubated for 5 mins pr...

Eur J Med Chem 54: 512-21 (2012)


Article DOI: 10.1016/j.ejmech.2012.05.041
BindingDB Entry DOI: 10.7270/Q2HM59HT
More data for this
Ligand-Target Pair