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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-A2/Cyclin-dependent kinase 2' and Ligand = 'BDBM50444665'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-A2/Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50444665
PNG
(CHEMBL3098657)
Show SMILES [#6]-[#6]-[#8]-c1cccc(n1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(F)cc1)-[#6](-[#8])=O |r|
Show InChI InChI=1S/C33H46FN9O8/c1-4-51-27-9-5-7-21(39-27)28(45)40-22(8-6-14-38-33(36)37)29(46)41-23(15-18(2)3)30(47)42-24(17-26(35)44)31(48)43-25(32(49)50)16-19-10-12-20(34)13-11-19/h5,7,9-13,18,22-25H,4,6,8,14-17H2,1-3H3,(H2,35,44)(H,40,45)(H,41,46)(H,42,47)(H,43,48)(H,49,50)(H4,36,37,38)/t22-,23-,24-,25-/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.97E+4n/an/an/an/an/an/a



University of South Carolina

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK2/cyclin A using fluoresceinyl-Ahx-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly as substrate after 45 mins by fluorescence pola...


Bioorg Med Chem 22: 616-22 (2013)


Article DOI: 10.1016/j.bmc.2013.10.039
BindingDB Entry DOI: 10.7270/Q2416ZHS
More data for this
Ligand-Target Pair