Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-A2 [177-432]/Cyclin-dependent kinase 2' and Ligand = 'BDBM35190'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM35190 (pyrazolo[3,4-b]-pyridine, 2) Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(C(=O)NC3CC3)c2cc1Br Show InChI InChI=1S/C16H13BrN4O2/c17-12-7-11-14(16(23)18-9-3-4-9)20-21-15(11)19-13(12)8-1-5-10(22)6-2-8/h1-2,5-7,9,22H,3-4H2,(H,18,23)(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	25
Pfizer					Assay Description Active cyclin dependent kinase 2 (CDK2) activity was determined by measuring the phosphorylation of Histone type 3 (Sigma H5505), in the presence of ...				Bioorg Med Chem Lett 19: 908-11 (2009) Article DOI: 10.1016/j.bmcl.2008.11.105 BindingDB Entry DOI: 10.7270/Q2G73C1H
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