Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 12 (Homo sapiens) | BDBM50139171 (Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02184 BindingDB Entry DOI: 10.7270/Q26114CS | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 12 (Homo sapiens) | BDBM50139171 (Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human CDK12 (696 to 1082 residues)/human cyclinK (1 to 267 residues) using pol2 CTD-peptide substrate and [gammaP]ATP by scintillation ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00766 BindingDB Entry DOI: 10.7270/Q2GX4G9M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 12 (Homo sapiens) | BDBM50139171 (Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2022.114603 BindingDB Entry DOI: 10.7270/Q28K7F2W | ||||||||||||
More data for this Ligand-Target Pair |