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Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 2/G1/S-specific cyclin-E1' and Ligand = 'BDBM50521560'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1


(Homo sapiens (Human))		BDBM50521560
PNG
(CHEMBL4555088)
Show SMILES CC(O)CSc1nc(NCc2ccc(cc2)-c2ccccn2)c2[nH]nc(C(C)C)c2n1
Show InChI InChI=1S/C23H26N6OS/c1-14(2)19-20-21(29-28-19)22(27-23(26-20)31-13-15(3)30)25-12-16-7-9-17(10-8-16)18-6-4-5-11-24-18/h4-11,14-15,30H,12-13H2,1-3H3,(H,28,29)(H,25,26,27)
PDB

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PC cid
PC sid
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Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CDK2/Cyclin-E1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using histone H1 as substrate measured in...

J Med Chem 62: 4606-4623 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00189
BindingDB Entry DOI: 10.7270/Q2G1647C
More data for this
Ligand-Target Pair