Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 4' and Ligand = 'BDBM147020'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM147020 (US8957074, 59) Show SMILES CSCC[C@@H](N)C(=O)N1C2CCC1CN(C2)C(=O)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)nc1 |r,THB:16:14:8:10.11| Show InChI InChI=1S/C31H41N9O3S/c1-37(2)30(43)25-14-20-16-34-31(36-27(20)40(25)21-6-4-5-7-21)35-26-11-8-19(15-33-26)28(41)38-17-22-9-10-23(18-38)39(22)29(42)24(32)12-13-44-3/h8,11,14-16,21-24H,4-7,9-10,12-13,17-18,32H2,1-3H3,(H,33,34,35,36)/t22?,23?,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
Novartis AG US Patent					Assay Description An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ...				US Patent US8957074 (2015) BindingDB Entry DOI: 10.7270/Q2K0730S
					More data for this Ligand-Target Pair