Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 8' and Ligand = 'BDBM50154961'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50154961 (CHEMBL3774959) Show SMILES COC1CN(C1)C(=O)c1ccc2[nH]nc(Cc3ccc4n(C)ncc4c3)c2c1 Show InChI InChI=1S/C21H21N5O2/c1-25-20-6-3-13(7-15(20)10-22-25)8-19-17-9-14(4-5-18(17)23-24-19)21(27)26-11-16(12-26)28-2/h3-7,9-10,16H,8,11-12H2,1-2H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...				Bioorg Med Chem Lett 26: 1443-51 (2016) Article DOI: 10.1016/j.bmcl.2016.01.062 BindingDB Entry DOI: 10.7270/Q2NZ89G6
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