Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Cystic fibrosis transmembrane conductance regulator' and Ligand = 'BDBM221944'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Cricetulus griseus (Chinese hamster))	BDBM221944 (US9303035, 1.12) Show SMILES Cn1ccc(n1)C1NCCn2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1 Show InChI InChI=1S/C21H22N6O2/c1-24-11-9-14(23-24)16-19-18-15(20(28)26(3)21(29)25(18)2)17(27(19)12-10-22-16)13-7-5-4-6-8-13/h4-9,11,16,22H,10,12H2,1-3H3	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.8	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CFTR activity can be quantified by electrophysiology methods, using the whole-cell configuration of the patch clamp technique (Hamill O, Marty A, Neh...				US Patent US9303035 (2016) BindingDB Entry DOI: 10.7270/Q2SQ8Z7R
					More data for this Ligand-Target Pair