Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50353386 (CHEMBL1829763 | US8592410, 88 | US8592410, Compara...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description The assay was based on a method published by Moody et al. (Xenobiotica 1999). The inhibition of cytochrome P450 3A4-isoenzyme catalysed N-demethylati... | US Patent US8592410 (2013) BindingDB Entry DOI: 10.7270/Q2CF9NRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50353386 (CHEMBL1829763 | US8592410, 88 | US8592410, Compara...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human CYP3A4 assessed as rate of [14C]-formaldehyde/formic acid production by liquid scintillation counting | J Med Chem 54: 6050-62 (2011) Article DOI: 10.1021/jm2005354 BindingDB Entry DOI: 10.7270/Q2P26ZH3 | |||||||||||
More data for this Ligand-Target Pair |