Found 43 hits Enz. Inhib. hit(s) with Target = 'D(1A) dopamine receptor' and Ligand = 'BDBM50001955' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D(1A) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 0.460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 253: 214-20 (1990)
BindingDB Entry DOI: 10.7270/Q2PN9447 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assay |
ACS Med Chem Lett 2: 189-194 (2011)
Article DOI: 10.1021/ml1001689 BindingDB Entry DOI: 10.7270/Q2Z89DF8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 12: 800-12 (1976)
BindingDB Entry DOI: 10.7270/Q22B8WH6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes |
J Med Chem 29: 1904-12 (1986)
BindingDB Entry DOI: 10.7270/Q2TQ623R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting |
Bioorg Med Chem 17: 4756-62 (2009)
Article DOI: 10.1016/j.bmc.2009.04.047 BindingDB Entry DOI: 10.7270/Q2KD1XZ4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter |
Eur J Med Chem 46: 2992-9 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.028 BindingDB Entry DOI: 10.7270/Q2X34XTG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université Catholique de Louvain
Curated by PDSP Ki Database
| |
Life Sci 37: 1971-83 (1985)
Article DOI: 10.1016/0024-3205(85)90028-1 BindingDB Entry DOI: 10.7270/Q2HX1B5B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Mus musculus (Mouse)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 101 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Debrecen
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells |
Bioorg Med Chem 16: 4563-8 (2008)
Article DOI: 10.1016/j.bmc.2008.02.038 BindingDB Entry DOI: 10.7270/Q24J0DW0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Camerino
Curated by ChEMBL
| Assay Description Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand. |
J Med Chem 43: 599-608 (2000)
Article DOI: 10.1021/jm991034o BindingDB Entry DOI: 10.7270/Q2X35161 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH-23390 from rat dopamine D1 receptor |
J Med Chem 50: 171-81 (2007)
Article DOI: 10.1021/jm060959i BindingDB Entry DOI: 10.7270/Q22J6CPJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| >221 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand |
J Med Chem 37: 3523-33 (1994)
BindingDB Entry DOI: 10.7270/Q2GT5M68 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 236 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand |
J Med Chem 33: 1800-5 (1990)
BindingDB Entry DOI: 10.7270/Q2K35SMD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 236 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1 |
J Med Chem 39: 3503-13 (1996)
Article DOI: 10.1021/jm960189i BindingDB Entry DOI: 10.7270/Q2T43S6S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 236 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]-SCH-23,390 displacement. |
J Med Chem 39: 3491-502 (1996)
Article DOI: 10.1021/jm960188q BindingDB Entry DOI: 10.7270/Q2XW4HXS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 236 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description Ability to displace [3H]-SCH-23,390 binding to rat striatal Dopamine receptor D1 |
J Med Chem 38: 647-58 (1995)
BindingDB Entry DOI: 10.7270/Q2HX1BQH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University
Curated by ChEMBL
| Assay Description Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes |
J Med Chem 33: 39-44 (1990)
BindingDB Entry DOI: 10.7270/Q2183732 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells |
Bioorg Med Chem 16: 6675-81 (2008)
Article DOI: 10.1016/j.bmc.2008.05.077 BindingDB Entry DOI: 10.7270/Q2SB45KD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 303: 791-804 (2002)
Article DOI: 10.1124/jpet.102.039867 BindingDB Entry DOI: 10.7270/Q2MG7N2F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
City University of New York
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2020.127053 BindingDB Entry DOI: 10.7270/Q2H135KF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SRI International
Curated by PDSP Ki Database
| |
NIDA Res Monogr 178: 440-66 (1998)
BindingDB Entry DOI: 10.7270/Q23J3BH2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 432 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by PDSP Ki Database
| |
Life Sci 35: 1885-93 (1984)
Article DOI: 10.1016/0024-3205(84)90540-x BindingDB Entry DOI: 10.7270/Q2JD4V9M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assay |
ACS Med Chem Lett 2: 189-194 (2011)
Article DOI: 10.1021/ml1001689 BindingDB Entry DOI: 10.7270/Q2Z89DF8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tartu
Curated by ChEMBL
| Assay Description Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells |
Eur J Med Chem 55: 255-61 (2012)
Article DOI: 10.1016/j.ejmech.2012.07.025 BindingDB Entry DOI: 10.7270/Q2VT1T56 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Nature 350: 614-9 (1991)
Article DOI: 10.1038/350614a0 BindingDB Entry DOI: 10.7270/Q2NV9GQR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| 888 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania
Curated by ChEMBL
| Assay Description In vitro binding affinity of the compound towards Dopamine receptor D1 by displacing [125I]-FISCH radioligand in rat striatal homogenate |
J Med Chem 32: 1431-5 (1989)
BindingDB Entry DOI: 10.7270/Q2KD1WWT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(BOVINE) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
Reactome pathway KEGG
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| 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 253: 214-20 (1990)
BindingDB Entry DOI: 10.7270/Q2PN9447 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1 |
Bioorg Med Chem Lett 3: 639-644 (1993)
Article DOI: 10.1016/S0960-894X(01)81245-2 BindingDB Entry DOI: 10.7270/Q2222V75 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description Compound was tested in vitro for binding affinity towards dopamine Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radiolig... |
J Med Chem 34: 2736-46 (1991)
BindingDB Entry DOI: 10.7270/Q2V125FC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined |
J Med Chem 33: 311-7 (1990)
BindingDB Entry DOI: 10.7270/Q28S4QHZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand. |
Bioorg Med Chem Lett 1: 189-192 (1991)
Article DOI: 10.1016/S0960-894X(00)80249-8 BindingDB Entry DOI: 10.7270/Q2ZC83BV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated in vitro for binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]-SCH-23,390 |
Bioorg Med Chem Lett 1: 539-544 (1991)
Article DOI: 10.1016/S0960-894X(01)80462-5 BindingDB Entry DOI: 10.7270/Q22807HM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Crete
Curated by ChEMBL
| Assay Description Inhibitition of binding of [3H]-SCH-23,390 to Dopamine receptor D1 in rat striatal membranes |
Bioorg Med Chem Lett 11: 883-6 (2001)
BindingDB Entry DOI: 10.7270/Q2XD10XM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 432 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro binding affinity towards rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement. |
J Med Chem 33: 600-7 (1990)
BindingDB Entry DOI: 10.7270/Q2XS5TCP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | 444 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Biochemicals Inc.
Curated by ChEMBL
| Assay Description Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane |
J Med Chem 33: 3122-4 (1991)
BindingDB Entry DOI: 10.7270/Q2G15ZS3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(RAT) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| PDB PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes |
J Med Chem 33: 2408-12 (1990)
BindingDB Entry DOI: 10.7270/Q29G5NFT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a |
University Centre for Pharmacy
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production |
Bioorg Med Chem 16: 3438-44 (2008)
Article DOI: 10.1016/j.bmc.2007.06.036 BindingDB Entry DOI: 10.7270/Q2PK0H0W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a |
VA Medical Center
Curated by ChEMBL
| Assay Description Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells |
J Med Chem 39: 850-9 (1996)
Article DOI: 10.1021/jm950447w BindingDB Entry DOI: 10.7270/Q2XG9RT3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arresti... |
ACS Med Chem Lett 11: 385-392 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00575 BindingDB Entry DOI: 10.7270/Q25X2D8S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 521 | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arresti... |
ACS Med Chem Lett 11: 385-392 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00575 BindingDB Entry DOI: 10.7270/Q25X2D8S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo... |
ACS Med Chem Lett 11: 385-392 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00575 BindingDB Entry DOI: 10.7270/Q25X2D8S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50001955
((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)Show InChI InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 | PDB
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| n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo... |
ACS Med Chem Lett 11: 385-392 (2020)
Article DOI: 10.1021/acsmedchemlett.9b00575 BindingDB Entry DOI: 10.7270/Q25X2D8S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |