BindingDB PrimarySearch

Found 19 hits Enz. Inhib. hit(s) with Target = 'D(1A) dopamine receptor' and Ligand = 'BDBM50004923'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				J Med Chem 34: 3366-71 (1992) BindingDB Entry DOI: 10.7270/Q26H4J17
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1				J Med Chem 34: 3366-71 (1992) BindingDB Entry DOI: 10.7270/Q26H4J17
Northeastern University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Bioorg Med Chem 11: 1451-64 (2003) Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Bioorg Med Chem 11: 1451-64 (2003) Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	26.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by PDSP K_i Database									Eur J Pharmacol 474: 137-40 (2003) Article DOI: 10.1016/s0014-2999(03)02008-9 BindingDB Entry DOI: 10.7270/Q2DN43MQ
Harvard University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Formation of cAMP on Dopamine receptor D2 in vitro in rat intermediate lobe				J Med Chem 33: 2948-50 (1990) BindingDB Entry DOI: 10.7270/Q2QV3N4J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)				J Med Chem 33: 2948-50 (1990) BindingDB Entry DOI: 10.7270/Q2QV3N4J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Bioorg Med Chem 11: 1451-64 (2003) Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells				Bioorg Med Chem 16: 9425-31 (2008) Article DOI: 10.1016/j.bmc.2008.09.049 BindingDB Entry DOI: 10.7270/Q2RN37P0
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	393	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica (SIMM) Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition bi...				Eur J Med Chem 85: 16-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.059 BindingDB Entry DOI: 10.7270/Q2PZ5BK4
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by PDSP K_i Database									Bioorg Med Chem 11: 1451-64 (2003) Article DOI: 10.1016/S0968-0896(02)00561-8 BindingDB Entry DOI: 10.7270/Q2CV4G90
Purdue University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Research Biochemicals Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum				J Med Chem 35: 1466-71 (1992) BindingDB Entry DOI: 10.7270/Q26H4GCW
Research Biochemicals Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay				Bioorg Med Chem 20: 4862-71 (2012) Article DOI: 10.1016/j.bmc.2012.05.057 BindingDB Entry DOI: 10.7270/Q28P61K9
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillatio...				Bioorg Med Chem 21: 856-68 (2013) Article DOI: 10.1016/j.bmc.2012.12.016 BindingDB Entry DOI: 10.7270/Q2JD4Z4M
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	386	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Formation of cAMP on Dopamine receptor D1 in vitro in carp retina				J Med Chem 33: 2948-50 (1990) BindingDB Entry DOI: 10.7270/Q2QV3N4J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay				Bioorg Med Chem 22: 5838-46 (2014) Article DOI: 10.1016/j.bmc.2014.09.024 BindingDB Entry DOI: 10.7270/Q2NC62SQ
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	248	n/a	n/a	7.5	n/a
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US Patent					Assay Description For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30� C. for 40 mins in reaction buffer containin...				US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	7.5	n/a
Fudan University					Assay Description The [35S]GTPγS binding assay was performed at 30 �C for 30 min containing 10 μgof membrane protein in a final volume of 100 μL with va...				Chem Biol Drug Des 88: 599-607 (2016) Article DOI: 10.1111/cbdd.12796 BindingDB Entry DOI: 10.7270/Q2QF8RQ5
Fudan University					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50004923 ((+/-)-SKF-38393 \| 1-Phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	386	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Formation of cAMP on Dopamine receptor D1 in vitro in carp retina				J Med Chem 33: 2948-50 (1990) BindingDB Entry DOI: 10.7270/Q2QV3N4J
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair