BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'D(3) dopamine receptor' and Ligand = 'BDBM50057767'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50057767 (CHEMBL3323017 \| US9598387, Compound 116 \| US996974...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human D3R expressed in HEK293 cell membranes by gamma counting method				J Med Chem 57: 7042-60 (2014) Article DOI: 10.1021/jm500801r BindingDB Entry DOI: 10.7270/Q27D2WSR
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50057767 (CHEMBL3323017 \| US9598387, Compound 116 \| US996974...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2HD7Z0N
Universita degli Studi di Roma La Sapienza					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50057767 (CHEMBL3323017 \| US9598387, Compound 116 \| US996974...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute US Patent					Assay Description The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...				US Patent US9598387 (2017) BindingDB Entry DOI: 10.7270/Q2QZ2D1Z
Southern Research Institute US Patent					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50057767 (CHEMBL3323017 \| US9598387, Compound 116 \| US996974...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Antagonist activity against D3R in human U2OS cells assessed as inhibition of (+)-PD128907-induced beta-arrestin translocation by beta-galactosidase ...				J Med Chem 57: 7042-60 (2014) Article DOI: 10.1021/jm500801r BindingDB Entry DOI: 10.7270/Q27D2WSR
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50057767 (CHEMBL3323017 \| US9598387, Compound 116 \| US996974...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	637	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs by [3H]thymidine u...				J Med Chem 57: 7042-60 (2014) Article DOI: 10.1021/jm500801r BindingDB Entry DOI: 10.7270/Q27D2WSR
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair