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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50033776'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50033776
PNG
(7-[5,6-Difluoro-2-oxo-1,2-dihydro-indol-(3E)-ylide...)
Show SMILES CCC1(O)C(=O)OCc2c1cc1C(=O)\C(Cn1c2=O)=C1\C(=O)Nc2cc(F)c(F)cc12
Show InChI InChI=1S/C21H14F2N2O6/c1-2-21(30)11-4-15-17(26)9(6-25(15)19(28)10(11)7-31-20(21)29)16-8-3-12(22)13(23)5-14(8)24-18(16)27/h3-5,30H,2,6-7H2,1H3,(H,24,27)/b16-9+
PDB

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antibodypedia
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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine topoisomerase I, using cleavable complex assay.

J Med Chem 38: 906-11 (1995)


BindingDB Entry DOI: 10.7270/Q2XG9Q55
More data for this
Ligand-Target Pair