BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50033778'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50033778
PNG
((R)-4-Ethyl-4-hydroxy-7-[2-oxo-1,2-dihydro-indol-(...)
Show SMILES CC[C@]1(O)C(=O)OCc2c1cc1C(=O)\C(Cn1c2=O)=C1\C(=O)Nc2ccccc12
Show InChI InChI=1S/C21H16N2O6/c1-2-21(28)13-7-15-17(24)11(8-23(15)19(26)12(13)9-29-20(21)27)16-10-5-3-4-6-14(10)22-18(16)25/h3-7,28H,2,8-9H2,1H3,(H,22,25)/b16-11+/t21-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine topoisomerase I, using cleavable complex assay.

J Med Chem 38: 906-11 (1995)


BindingDB Entry DOI: 10.7270/Q2XG9Q55
More data for this
Ligand-Target Pair