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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibitory concentration against DNA topoisomerase I activity | Bioorg Med Chem Lett 15: 2065-8 (2005) Article DOI: 10.1016/j.bmcl.2005.02.052 BindingDB Entry DOI: 10.7270/Q2WH2R6D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 1 (Cercopithecus aethiops) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 1 (Mus musculus) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA topoisomerase 1 (Homo sapiens (Human)) | BDBM50164888 (6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form | J Nat Prod 64: 204-7 (2001) BindingDB Entry DOI: 10.7270/Q2W37W21 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
