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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50203038'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50203038
PNG
(CHEMBL3975075)
Show SMILES [Br-].Cc1cc2cc[n+](Cc3ccccc3)c3-c4ccccc4-c(n1)c23
Show InChI InChI=1S/C22H17N2/c1-15-13-17-11-12-24(14-16-7-3-2-4-8-16)22-19-10-6-5-9-18(19)21(23-15)20(17)22/h2-13H,14H2,1H3/q+1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.08E+4n/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DNA topoisomerase 1 using pHOT1 as substrate after 30 mins by agarose gel electrophoresis

Bioorg Med Chem 24: 6119-6130 (2016)


Article DOI: 10.1016/j.bmc.2016.02.028
BindingDB Entry DOI: 10.7270/Q2BG2QZJ
More data for this
Ligand-Target Pair