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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50203044'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 1


(Homo sapiens (Human))		BDBM50203044
PNG
(CHEMBL3960953)
Show SMILES [Br-].C(c1ccccc1)[n+]1ccc2cc(nc3-c4ccccc4-c1c23)-c1ccccc1
Show InChI InChI=1S/C27H19N2/c1-3-9-19(10-4-1)18-29-16-15-21-17-24(20-11-5-2-6-12-20)28-26-22-13-7-8-14-23(22)27(29)25(21)26/h1-17H,18H2/q+1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.74E+3n/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human DNA topoisomerase 1 using pHOT1 as substrate after 30 mins by agarose gel electrophoresis

Bioorg Med Chem 24: 6119-6130 (2016)


Article DOI: 10.1016/j.bmc.2016.02.028
BindingDB Entry DOI: 10.7270/Q2BG2QZJ
More data for this
Ligand-Target Pair