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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha/2-beta' and Ligand = 'BDBM50471783'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha/2-beta


(Homo sapiens (Human))		BDBM50471783
PNG
(CHEMBL121666)
Show SMILES CCN(CC)CCNc1ccc(CNS(C)(=O)=O)c2sc3ccc(O)cc3c(=O)c12
Show InChI InChI=1S/C21H27N3O4S2/c1-4-24(5-2)11-10-22-17-8-6-14(13-23-30(3,27)28)21-19(17)20(26)16-12-15(25)7-9-18(16)29-21/h6-9,12,22-23,25H,4-5,10-11,13H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

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GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 500n/an/an/an/a



Sanofi Winthrop Inc.

Curated by ChEMBL


Assay Description
In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.

J Med Chem 41: 3645-54 (1998)


Article DOI: 10.1021/jm9708083
BindingDB Entry DOI: 10.7270/Q2GB26SZ
More data for this
Ligand-Target Pair