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Found 2 hits Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM50259215'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50259215
PNG
(CHEMBL4064887 | US10266550, Compound 11b)
Show SMILES Nc1ccc2c(c1)oc1c(N3CCNCC3)c(F)cc3c1n2cc(C(O)=O)c3=O
Show InChI InChI=1S/C20H17FN4O4/c21-13-8-11-16-19(17(13)24-5-3-23-4-6-24)29-15-7-10(22)1-2-14(15)25(16)9-12(18(11)26)20(27)28/h1-2,7-9,23H,3-6,22H2,(H,27,28)
PDB

UniProtKB/SwissProt

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PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.95E+3n/an/an/an/an/an/a



University of Hawaii at Hilo

Curated by ChEMBL


Assay Description
Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...

Eur J Med Chem 125: 515-527 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.053
BindingDB Entry DOI: 10.7270/Q2445PXH
More data for this
Ligand-Target Pair
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50259215
PNG
(CHEMBL4064887 | US10266550, Compound 11b)
Show SMILES Nc1ccc2c(c1)oc1c(N3CCNCC3)c(F)cc3c1n2cc(C(O)=O)c3=O
Show InChI InChI=1S/C20H17FN4O4/c21-13-8-11-16-19(17(13)24-5-3-23-4-6-24)29-15-7-10(22)1-2-14(15)25(16)9-12(18(11)26)20(27)28/h1-2,7-9,23H,3-6,22H2,(H,27,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2.93E+3n/an/an/an/an/an/a



University of Bath



Assay Description
Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...

J Med Chem 51: 4226-38 (2008)


BindingDB Entry DOI: 10.7270/Q2H997HD
More data for this
Ligand-Target Pair