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Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM50308985'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50308985
PNG
(CHEMBL592862 | Diazirine)
Show SMILES COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](NC(=O)c2ccc(cc2)C2(N=N2)C(F)(F)F)c2cc3OCOc3cc12 |r,c:32|
Show InChI InChI=1S/C30H24F3N3O8/c1-40-21-7-14(8-22(41-2)26(21)37)23-16-9-19-20(44-12-43-19)10-17(16)25(18-11-42-28(39)24(18)23)34-27(38)13-3-5-15(6-4-13)29(35-36-29)30(31,32)33/h3-10,18,23-25,37H,11-12H2,1-2H3,(H,34,38)/t18-,23+,24-,25+/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.14E+5n/an/an/an/an/an/a



University of Manitoba

Curated by ChEMBL


Assay Description
Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast plasmid DNA by fluorescent plate reader

Bioorg Med Chem 18: 830-8 (2010)


Article DOI: 10.1016/j.bmc.2009.11.048
BindingDB Entry DOI: 10.7270/Q2KH0P8X
More data for this
Ligand-Target Pair