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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 4 subunit A' and Ligand = 'BDBM50178886'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 4 subunit A


(Staphylococcus aureus)		BDBM50178886
PNG
(9-cyclopropyl-6-fluoro-7-(1H-pyrrol-2-yl)isothiazo...)
Show SMILES Fc1cc2c(cc1-c1ccc[nH]1)n(C1CC1)c1s[nH]c(=O)c1c2=O
Show InChI InChI=1S/C17H12FN3O2S/c18-11-6-10-13(7-9(11)12-2-1-5-19-12)21(8-3-4-8)17-14(15(10)22)16(23)20-24-17/h1-2,5-8,19H,3-4H2,(H,20,23)
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Article
PubMed
n/an/a 9.90E+3n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4

Bioorg Med Chem Lett 16: 1277-81 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.064
BindingDB Entry DOI: 10.7270/Q26D5SKN
More data for this
Ligand-Target Pair