Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase I subunit RPA1' and Ligand = 'BDBM50019309'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019309 (CHEMBL3289414) Show SMILES CN1CCC(CC1)NC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C23H22N4O2/c1-26-11-8-17(9-12-26)24-22(28)18-7-4-10-27-21(18)25-20-14-16-6-3-2-5-15(16)13-19(20)23(27)29/h2-7,10,13-14,17H,8-9,11-12H2,1H3,(H,24,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
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