Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase I subunit RPA1' and Ligand = 'BDBM50019322'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019322 (CHEMBL3289427) Show SMILES CN1CCN(CCNC(=O)c2cccn3c2nc2cc4ccccc4cc2c3=O)CC1 Show InChI InChI=1S/C24H25N5O2/c1-27-11-13-28(14-12-27)10-8-25-23(30)19-7-4-9-29-22(19)26-21-16-18-6-3-2-5-17(18)15-20(21)24(29)31/h2-7,9,15-16H,8,10-14H2,1H3,(H,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
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