Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase I subunit RPA1' and Ligand = 'BDBM50019324'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019324 (CHEMBL3289398) Show SMILES CN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis				J Med Chem 57: 4950-61 (2014) Article DOI: 10.1021/jm5004842 BindingDB Entry DOI: 10.7270/Q2M0470M
					More data for this Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1 (Homo sapiens (Human))	BDBM50019324 (CHEMBL3289398) Show SMILES CN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O Show InChI InChI=1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of RNA polymerase 1 in human A-375 assessed as RPA194 degradation measured after 4 hrs by Hoechst 33342 staining based assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00660 BindingDB Entry DOI: 10.7270/Q2KW5KXW
					More data for this Ligand-Target Pair