Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM176291'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM176291 (US9688696, 6) Show SMILES CC(c1ccccc1)n1ncn(-c2ccc(cc2)N2CCN(CC2)C(=O)Nc2c(Cl)cccc2Cl)c1=O Show InChI InChI=1S/C27H26Cl2N6O2/c1-19(20-6-3-2-4-7-20)35-27(37)34(18-30-35)22-12-10-21(11-13-22)32-14-16-33(17-15-32)26(36)31-25-23(28)8-5-9-24(25)29/h2-13,18-19H,14-17H2,1H3,(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	302	n/a	n/a	n/a	n/a	7.4	25
Janssen Pharmaceutica N.V. US Patent					Assay Description DGAT activity in membrane preparations was assayed in 50 mM Tris-HCl (pH 7.4), 150 mM MgCl2, 1 mM EDTA and 0.2% BSA, containing 50 μM DAG, 32 &#...				US Patent US9688696 (2017) BindingDB Entry DOI: 10.7270/Q24X55ZP
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