Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020053' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020053
(CHEMBL3287867)Show SMILES CCC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:27.30,wD:30.34,(2.93,-11.98,;4.47,-11.98,;5.24,-10.65,;4.47,-9.32,;5.24,-7.98,;4.47,-6.65,;5.24,-5.31,;2.93,-6.65,;2.16,-5.31,;.62,-5.31,;-.15,-3.98,;.62,-2.65,;2.16,-2.65,;2.93,-3.98,;6.78,-7.98,;7.55,-6.65,;9.09,-6.65,;9.86,-7.98,;9.09,-9.32,;7.55,-9.32,;6.78,-10.65,;11.4,-7.98,;12.17,-9.32,;13.71,-9.32,;14.48,-7.98,;13.71,-6.65,;12.17,-6.65,;16.02,-7.98,;16.79,-6.65,;18.33,-6.65,;19.1,-7.98,;20.64,-7.98,;21.41,-9.32,;22.95,-9.32,;20.64,-10.65,;18.33,-9.32,;16.79,-9.32,)| Show InChI InChI=1S/C31H34N2O4/c1-2-27-20-33(31(36)32-26-6-4-3-5-7-26)28-17-16-25(19-29(28)37-27)24-14-12-23(13-15-24)22-10-8-21(9-11-22)18-30(34)35/h3-7,12-17,19,21-22,27H,2,8-11,18,20H2,1H3,(H,32,36)(H,34,35)/t21-,22-,27? | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020053
(CHEMBL3287867)Show SMILES CCC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:27.30,wD:30.34,(2.93,-11.98,;4.47,-11.98,;5.24,-10.65,;4.47,-9.32,;5.24,-7.98,;4.47,-6.65,;5.24,-5.31,;2.93,-6.65,;2.16,-5.31,;.62,-5.31,;-.15,-3.98,;.62,-2.65,;2.16,-2.65,;2.93,-3.98,;6.78,-7.98,;7.55,-6.65,;9.09,-6.65,;9.86,-7.98,;9.09,-9.32,;7.55,-9.32,;6.78,-10.65,;11.4,-7.98,;12.17,-9.32,;13.71,-9.32,;14.48,-7.98,;13.71,-6.65,;12.17,-6.65,;16.02,-7.98,;16.79,-6.65,;18.33,-6.65,;19.1,-7.98,;20.64,-7.98,;21.41,-9.32,;22.95,-9.32,;20.64,-10.65,;18.33,-9.32,;16.79,-9.32,)| Show InChI InChI=1S/C31H34N2O4/c1-2-27-20-33(31(36)32-26-6-4-3-5-7-26)28-17-16-25(19-29(28)37-27)24-14-12-23(13-15-24)22-10-8-21(9-11-22)18-30(34)35/h3-7,12-17,19,21-22,27H,2,8-11,18,20H2,1H3,(H,32,36)(H,34,35)/t21-,22-,27? | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this Ligand-Target Pair | |